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UC San Diego Researchers Convert Pro-Tumor …

1 days ago UC San Diego Researchers Convert Pro-Tumor Macrophages into Cancer Killers. Epithelial cancers, such as cancers of the lung and pancreas, use the ανβ3 molecule to gain drug resistance to standard cancer therapies and to become highly metastatic. In a paper published in Cancer Research, University of California San Diego School of Medicine ucsd health system

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How Brain Tumors Turn Immune Cells into Cancer …

3 days ago “These cancer cells appear to ‘brainwash’ our own immune cells and convert them from cells that fight cancer to cells that promote cancer,” said Judith Varner, PhD, professor in the departments of Pathology and Medicine at UC San Diego School of Medicine and co-senior author of the study. ucsd health center

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Cardioversion UC San Diego Health

3 days ago Cardioversion is usually performed when medications have failed to restore a patient's abnormal rhythm back to a normal sinus rhythm. External cardioversion is performed by delivering high-energy shocks of 50 to 300 joules through two defibrillator pads attached to the chest, to convert an abnormal heart rhythm back to normal. uc health ucsd

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Social Justice as Part of the Remedy for What Ails Us

3 days ago There will be efforts to inform educators about curricular design and training in health care to convert research into practices that combat racism, and reframe the debate about health care disparities in terms of empathy and social justice. “This will require many facets of human endeavor,” said Patrick, “and the participation of faculty ucsd health jobs

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Melancholy Maybe: What You Should Know about SSRIs

8 days ago Codeine requires the activity of the cytochrome p450 2D6 enzyme to convert the drug to morphine. Certain SSRIs, such as Paxil, when taken with codeine can suppress pain relief. You should review your medication regimen with your physician or pharmacist regularly and alert them to any changes to the drugs you are taking. ucsd health portal

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Thyroid Disorders UC San Diego Health

7 days ago These hormones regulate the rate at which processes in the body (e.g., breathing, contracting muscles) convert and use energy (metabolism). Thyroid conditions include: Hyperthyroidism; Hypothyroidism; Thyroid nodules

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Good Vibrations: Using Light-Heated Water to Deliver …

3 days ago The new method described by Almutairi and colleagues in the departments of Mechanical and Aerospace Engineering, Neuroscience, and Chemistry and Biochemistry at UC San Diego uses NIR at a vibrational wavelength cued to excite water molecules, which absorb the optical energy and convert it to heat.

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Breaking Bad Mitochondria

8 days ago Mitochondria are organelles in a cell that convert energy from food (glucose) into a form of energy that can be used by cells called adenosine triphosphate. Specifically, the researchers discovered that the virus stimulates the production of a protein (Drp 1) that induces viral-damaged mitochondria to undergo asymmetric fragmentation.

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Q&A: Quantified Surgery

3 days ago So we were able to take the normal MRI or CT scan slices, convert them into 3D graphics and then take the part that was diseased, the sigmoid colon, print it out at life scale. I could see that there was an unusual kink in it and lots of diverticula.

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During COVID-19, Telehealth Reconnects Patients with

3 days ago In just four days, 1,000 face-to-face clinic appointments were successfully converted to telehealth visits. When COVID-19 arrived, Danielle Lovette and her husband, Corey Nigrelli, switched from in-person appointments to logging into the MyUCSDHealth app on a mobile device for a live, 45-minute speech therapy video visits.

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UC San Diego Researchers Identify How Skin Ages, Loses Fat

Just Now Some dermal fibroblasts can convert into fat cells that reside under the dermis, giving skin a youthful look and producing peptides that fight infections. University of California San Diego School of Medicine researchers and colleagues show how this happens and what causes it to stop as people age.

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All the Buzz about Bs

7 days ago B1, or thiamin, helps our bodies break down carbohydrates to convert glucose into usable energy. It’s also essential to maintaining a healthy brain . B9, or folic acid , supports “the creation of cells in the blood-forming organs and bone marrow, and in the proper development of the fetal spinal cord during pregnancy.”

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Study Reveals Connection Between Gut Bacteria and Vitamin

6 days ago In addition to discovering a link between active vitamin D and overall microbiome diversity, the researchers also noted that 12 particular types of bacteria appeared more often in the gut microbiomes of men with lots of active vitamin D. Most of those 12 bacteria produce butyrate, a beneficial fatty acid that helps maintain gut lining health.

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How Cells 'Read' Artificial Ingredients Tossed into

4 days ago Wang’s lab has long studied RNA polymerase II, an essential enzyme found in every fungal, plant and animal cell. RNA Pol II reads the DNA recipe and helps convert the genetic code into messenger RNA. (That mRNA then carries that genetic recipe out of the nucleus and into the cytoplasm, where it’s translated and used to assemble proteins as

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How Brain Biology Promotes Starvation in Patients with

3 days ago The finding indicates anxiety may contribute to starvation because it impairs the ability to start eating. The researchers said the findings suggest a powerful biology contributes to restricted eating behavior in AN, and that the findings provide new answers to how those with anorexia are able to become severely underweight.

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2019 Press Releases from UC San Diego Health

2 days ago UC San Diego Researchers Convert Pro-Tumor Macrophages into Cancer Killers. 8/21/2019. University of California San Diego School of Medicine researchers identified a new therapeutic approach in mouse models that halts drug resistance and cancer progression by using an antibody that indu

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Regulating Single Protein Prompts Fibroblasts to Become

4 days ago Repression of a single protein in ordinary fibroblasts is sufficient to directly convert the cells into functional neurons. The findings, which could have far-reaching implications for the development of new treatments for neurodegenerative diseases like Huntington’s, Parkinson’s and Alzheimer’s, will be published online in advance of the January 17 issue of the journal Cell.

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Sugar Molecule Links Red Meat Consumption and Elevated

3 days ago Red meat is rich in Neu5Gc, a non-human sugar found to promote inflammation and cancer progression in rodents. Varki’s team first conducted a systematic survey of common foods. They found that red meats (beef, pork and lamb) are rich in Neu5Gc, affirming that foods of mammalian origin such as these are the primary sources of Neu5Gc in the

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Sweet! How Glycogen is Linked to Heat Generation in Fat Cells

Just Now The turnover of glycogen sends a signal that it is safe for the cell to “uncouple” the production of ATP, the molecule that provides the energy that fuels most cellular processes. “Uncoupling is a way to generate heat, and in the process help balance energy. This pathway thus ensures that only the fat cells with enough energy stores to

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Using CRISPR to Reverse Retinitis Pigmentosa and Restore

6 days ago Retinitis pigmentosa (RP) is a group of inherited vision disorders caused by numerous mutations in more than 60 genes. The mutations affect the eyes’ photoreceptors, specialized cells in the retina that sense and convert light images into electrical signals sent to the brain. There are two types: rod cells that function for night vision and

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9 Reasons Why Eating Right Makes Good Senses

4 days ago In fact, numerous studies have shown that regular carrot consumption benefits eyesight, primarily because the vegetables are rich in beta-carotene, which the body uses to make vitamin A, which in turn is used by the eyes to convert light into nerve impulses that can be sent to the brain for interpretation. So go ahead and eat your carrots.

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Non-epileptic Events UC San Dieogo Health

8 days ago Non-epileptic events may result in “blacking out” briefly. There may be hyperventilation, trembling, shuddering or confusion. Visual disturbances, loss of speech, numbness or weakness may also occur. One or more limbs may undergo rhythmic shaking. Significant shaking of all four limbs may resemble a “grand mal” seizure.

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2018 Press Releases from UC San Diego Health

2 days ago Some dermal fibroblasts can convert into fat cells that reside under the dermis, giving skin a youthful look and producing peptides that fight infections. University of California San Diego School of

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Transplanting Good Bacteria to Kill Staph

1 days ago University of California San Diego School of Medicine researchers screened 10,000 colonies of bacteria found on the epidermis to determine how many had antimicrobial properties and at what rate these are found on healthy and non-healthy skin. In a paper published in Science Translation Medicine, the team reports isolating and growing good …

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New Cancer Immunotherapy Approach Turns Immune Cells into

8 days ago Once inside, through a naturally occurring process, the cells convert the precursor into mature, active miR-335 and package it into vesicles, small, membrane-coated sacs that bud off from the cell. Each B cell can produce 100,000 miR-335-containing vesicles per day — enough to treat 10 cancer cells.

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UC San Diego among First in Nation to Treat Brain Cancer

1 days ago Toca 511 is a retroviral replicating vector (RRV) that is designed to deliver a cytosine deaminase (CD) gene selectively to cancer cells. After allowing time for the administered Toca 511 to spread through the cancerous tumor those cancer cells expressing the CD gene can convert flucytosine into the anti-cancer drug 5-fluorouracil (5-FU).

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Researchers Operate Lab-Grown Heart Cells by Remote Control

9 days ago Graphene is a semi-metal made up of a latticework of carbon atoms, the same element that forms the basis of all living organisms. Part of what makes graphene special is its ability to efficiently convert light into electricity. In contrast, glass and plastic are insulators — they don’t conduct electricity.

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A New Approach to Faster Anticancer Drug Discovery

5 days ago The goal is to find new drugs or ways to convert these genes or the affected cells back to a normal state. In many disease paradigms, you don’t want to kill cells. You want to modify them to become healthy again.” While the idea of conducting multi-target screenings is not new, the technology to do so has been limited.

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UC San Diego Health Sciences Receives Gift for

7 days ago The disease occurs when the body’s immune system attacks and destroys certain cells that produce insulin – a hormone that helps the body convert food into energy. People with type 1 diabetes must frequently test their blood sugar and take insulin to stay alive, sometimes requiring multiple injections daily or delivering insulin through a pump.

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Rejuvenating Electron Microscopy

Just Now Established methods were then used to convert singlet oxygen production into a tissue stain that the electron microscope can see. The scientists tested the modified protein’s utility as an EM marker by first using it to confirm the locations of several already well-understood proteins in mammalian cells, nematodes and rodents, then used miniSOG to successfully tag two …

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Depriving Deadly Brain Tumors of Cholesterol May Be Their

8 days ago Researchers at University of California San Diego School of Medicine, Ludwig Institute for Cancer Research and The Scripps Research Institute, with colleagues in Los Angeles and Japan, report that depriving deadly brain cancer cells of cholesterol, which they import from neighboring healthy cells, specifically kills tumor cells and caused tumor regression and …

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Beneficial Skin Bacteria Protect Against Skin Cancer

2 days ago Beneficial Skin Bacteria Protect Against Skin Cancer. Science continues to peel away layers of the skin microbiome to reveal its protective properties. In a study published in Science Advances on February 28, University of California San Diego School of Medicine researchers report a potential new role for some bacteria on the skin: protecting

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Local Rotaries' Gift to UCSD Enhances Treatment for

4 days ago Mitochondria are the cellular structures that convert the potential energy provided by food into usable energy that sustains life and growth. They are also essential for many of the body’s metabolic functions. Mitochondrial dysfunction results in cell injury and organ failure. Steve Achard (kneeling in front) and fellow Rotary Club members

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Pro-inflammatory Enzyme Linked to Diabetes; Immune System

8 days ago Affecting 18.2 million Americans, diabetes is a disease in which the body does not produce or properly use insulin, a hormone necessary to convert sugar, starches and other food into energy needed for daily life. Previous studies in the past few years have implicated inflammation as playing a role in diabetes, but just how this occurred was

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Machine Learning Algorithm Can’t Distinguish These Lab

2 days ago In the lab, researchers convert the skin cells into induced pluripotent stem cells (iPSCs). Like most stem cells, with the right cocktail of molecular factors, iPSCs can be directed to specialize into any cell type. In this case, they become brain cells — different types of neurons and glia, for example.

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GenomeSpace “Recipes” Help Biologists Interpret Genomic Data

8 days ago Researchers at University of California, San Diego School of Medicine and collaborators developed GenomeSpace, a cloud-based, biologist-friendly platform that connects more than 20 bioinformatics software packages and resources for genomic data analysis. The team is now developing and crowdsourcing “recipes” — step-by-step workflows — to better …

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2013 Archived News Releases from UC San Diego Health

2 days ago Repression of a single protein in ordinary fibroblasts is sufficient to directly convert the cells into functional neurons. The findings, which could have far-reaching implications for the development

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CIRM Awards Three Awards to UCSD Researchers in Support of

2 days ago The California Institute for Regenerative Medicine (CIRM) has awarded three grants totaling nearly $5.8 million to researchers at the University of California, San Diego for development of innovative technologies designed to advance translational stem cell research. The grants are part of $32 million in Tools and Technology Awards II awarded to 19 projects at 10 California …

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UCSD Receives Nation’s First Fellowship in Mitochondrial

3 days ago Mitochondrial diseases can be confusing to diagnose and complex to manage, according to Haas. Responsible for creating a large percentage of the energy need by the body to sustain life and growth, mitochondria are the cellular structures that function to convert the potential energy provided by food into usable energy.

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Major NIH Grant Funds Novel Alzheimer’s Drug Development

4 days ago Public funding from the NIH has long helped academic labs and small businesses exploit their ingenuity to pursue new strategies for treating nervous system disorders. Most academic labs, however, lack the resources – time, money, scientific staff, and regulatory expertise – to convert these strategies into effective treatments.

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UCSD Researcher Receives NIH Transformative R01 Award for

3 days ago Retinal photoreceptors are light-sensing cells that convert complex external visual stimuli to electrical and chemical signals. Degeneration of these photoreceptors is the end point of the most common forms of irreversible blindness in humans, including age-related macular degeneration and retinitis pigmentosa, which affect more than 50 million

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Researchers Find Fertility Genes Required for Sperm Stem Cells

2 days ago For example, Rhox genes may have roles in testicular tumors that arise from germ cells that failed to convert into spermatogonial stem cells and thus are “frozen” at the pro-spermatogonia stage. Rhox genes may also be useful for regenerative medicine approaches to restoring fertility through therapy with spermatogonial stem cells.

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Study Sheds Light on How Pancreatic Cancer Begins

8 days ago The scientists show that activation of Sox9 is necessary to convert the acinar cells into premalignant lesions. Overexpression of the Sox9 gene enhances both abnormal, pancreatitis-associated changes in adult tissue cells and Kras-induced PanIN formation.

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UCSD Team Discovers Diabetes Trigger in Fatty Diet

6 days ago Proper insulin secretion is essential to enable the rest of the body to metabolize glucose and convert it to cellular energy. Analyzing mice lacking the GnT-4a gene, the researchers found that these mice had elevated blood glucose concentrations. In mice, as in humans, a high level of sugar in the blood is the first measure and diagnosis of

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